IDENTIFICATION OF A GENOMIC DNA SEQUENCE THAT QUANTITATIVELY MODULATES KLF1 TRANSCRIPTION FACTOR EXPRESSION IN DIFFERENTIATING HUMAN HEMATOPOIETIC CELLS

Abstract The onset of erythropoiesis is under strict developmental control, with direct and indirect inputs influencing its derivation from the hematopoietic stem cell.A major regulator of this transition is KLF1/EKLF, a zinc finger transcription factor that plays a global role in all aspects of erythropoiesis.Here, we have identified a short, cons

This study introduces a novel controller based on a Reinforcement Learning (RL) algorithm for real-time adaptation of the stimulation pattern during FES-cycling.Core to our approach is the introduction of an RL agent that interacts with the cycling environment and learns through trial and error how to modulate the electrical charge applied to the s

Vincent Lloyd’s 2016 book Black Natural Law presents four case histories in which African American intellectuals used the natural law tradition to mount defenses of the rights, capacities, and dignity of members of their communities.This essay uses the discourse of black natural law as reconstructed by Lloyd to reread Caliban’s delta ga